- No RX Needed
- Prescription and OTC
- Related Suggestions
- Generic Status
- Ratings & Reviews
- Side Effects
- Pricing and Coupons
- Dosage Form(s) Available
- Brand Names
- Half Life
- CSA Schedule **
- Pregnancy Category
- Drug Interactions
- Alcohol/Food/Lifestyle Interactions
- Disease Interactions
- First Approval Date
No RX Needed
This medication, containing codeine, pseudoephedrine, and pyrilamine, is prescribed for various symptoms such as allergies, cold symptoms, cough, cough and nasal congestion, nasal congestion, rhinorrhea, and sinus symptoms. It may also be used for other purposes not listed here.
Hydroxyzine is used to relieve anxiety or itching. However, it causes sedation and can affect a person’s ability to drive or operate machinery. It should not be used during pregnancy or while…
Prescription and OTC
Loratadine is an antihistamine that effectively treats allergic reactions such as hay fever. It is unlikely to cause drowsiness and is prescribed for allergic rhinitis, urticaria, and allergic…
Learn more about Hydroxyzine and Loratadine.
No lower-cost generic available for this medication.
Ratings & Reviews
Be the first to share your experience with this drug. Hydroxyzine has an average rating of 5.7 out of 10 from a total of 1318 ratings on Drugs.com. 45% of reviewers reported a positive effect, while 37% reported a negative effect. Loratadine has an average rating of 4.8 out of 10 from a total of 131 ratings on Drugs.com. 37% of reviewers reported a positive effect, while 54% reported a negative effect.
See also: codeine / pseudoephedrine / pyrilamine side effects in more detail. See also: hydroxyzine side effects in more detail. See also: loratadine side effects in more detail.
Pricing and Coupons
Prices are without insurance. We could not find an exact match for this medicine. Try searching the Price Guide directly.
View all hydroxyzine prices. View all loratadine prices.
Dosage Form(s) Available
Intramuscular solution, oral capsule, oral syrup, oral tablet, oral tablet, chewable, oral tablet, disintegrating.
Vistaril, Alavert, Allergy Relief 24 Hour, Allergy Relief Tablets, Bactimicina Allergy, Children’s Allergy Relief 24 Hour, Children’s Claritin Allergy, Claritin, Claritin 24 Hour Allergy, Claritin Reditabs, Clear-Atadine Children’s, Help I Have Allergies, Loratadine Reditab, ohm Allergy Relief, Tavist ND, Wal-itin.
The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. Hydroxyzine has a half-life of 16 hours. Loratadine has a half-life of 7 hours.
CSA Schedule **
Codeine / pseudoephedrine / pyrilamine has a low potential for abuse relative to those in schedule 4. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4. Hydroxyzine and loratadine are not subject to the Controlled Substances Act.
See the full pregnancy warnings document for each medication.
A total of 633 drugs are known to interact with codeine / pseudoephedrine / pyrilamine. A total of 557 drugs are known to interact with hydroxyzine. A total of 93 drugs are known to interact with loratadine.
Alcohol can increase the nervous system side effects of pyrilamine and hydroxyzine such as dizziness and drowsiness. No known alcohol/food interactions exist for loratadine, but always consult your healthcare provider.
No disease interactions were found for these medications.
First Approval Date
N/A for codeine / pseudoephedrine / pyrilamine. Hydroxyzine was approved on April 12, 1956, and loratadine was