Drugs A to Z
Potential Drug Interactions: Codeine and Rizatriptan
This report highlights the potential risks of combining codeine and rizatriptan, which can lead to a rare but serious condition known as serotonin syndrome. Symptoms of this condition include confusion, hallucinations, seizures, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. In severe cases, coma and death may occur. If you experience any of these symptoms during treatment, contact your doctor immediately. Combining these medications may also increase side effects such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. It is important to avoid or limit alcohol use while taking these medications and to avoid driving or operating hazardous machinery until you know how they affect you. Inform your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first consulting your doctor.
Drug and Food Interactions
No alcohol or food interactions were found. However, it is important to always consult your healthcare provider as this does not necessarily mean no interactions exist.
Therapeutic Duplication Warnings
No warnings were found for the selected drugs. Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Drug Interaction Classification
These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
- Major: Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
- Moderate: Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
- Minor: Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
- Unknown: No interaction information available.
Further Information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medical Disclaimer: This article is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare providers with any questions you may have regarding a medical condition.