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Potential Drug Interactions: Buprenorphine and Codeine
This report highlights the potential interactions between two drugs: buprenorphine and codeine.
Interactions between Your Drugs
Using codeine in combination with other medications that cause central nervous system depression, such as buprenorphine, can lead to serious side effects, including respiratory distress, coma, and even death. To safely use both medications, you may need a dose adjustment or more frequent monitoring by your doctor. Do not drink alcohol or self-medicate with these medications without your doctor’s approval, and do not exceed the doses or frequency and duration of use prescribed by your doctor. Additionally, you should avoid driving or operating hazardous machinery until you know how these medications affect you. If you have any questions or concerns, talk to your doctor or pharmacist. It is important to inform your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first consulting your doctor.
Drug and Food Interactions
No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Therapeutic Duplication Warnings
No warnings were found for your selected drugs. Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Drug Interaction Classification
These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
- Major: Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
- Moderate: Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
- Minor: Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
- Unknown: No interaction information available.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.