Interactions between Amitriptyline and codeine

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Potential Drug Interactions: Amitriptyline and Codeine

When used together, amitriptyline and codeine can increase the risk of a rare but serious condition called serotonin syndrome. Symptoms may include confusion, hallucinations, seizures, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. In severe cases, coma and even death may occur. If you experience any of these symptoms during treatment, contact your doctor immediately.

Combining these medications may also increase side effects such as dizziness, drowsiness, and difficulty concentrating. Some people may experience impairment in thinking and judgment. It is important to avoid or limit the use of alcohol while being treated with these medications and to avoid driving or operating hazardous machinery until you know how the medications affect you. Inform your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and Food Interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic Duplication Warnings

No warnings were found for your selected drugs. Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.

  • Major: Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
  • Moderate: Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
  • Minor: Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
  • Unknown: No interaction information available.

Further Information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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