Comparison between Codeine and Tramadol

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Prescription Only

Codeine is a pain-reliever that can be addictive and cause constipation. Its effectiveness varies between individuals, so it should only be used for pain relief under medical supervision.

Tramadol is a strong pain relief medicine that can cause dependence and side effects like nausea. Its effectiveness also varies between individuals, so it should only be used under medical supervision.

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Generic Status

Lower-cost generic versions of both codeine and tramadol are available.

Ratings & Reviews

Codeine has an average rating of 7.8 out of 10 from 60 ratings on Drugs.com, with 69% of reviewers reporting a positive effect.

Tramadol has an average rating of 6.8 out of 10 from 1793 ratings on Drugs.com, with 61% of reviewers reporting a positive effect.

Drug Class

Both codeine and tramadol belong to the opioid analgesics drug class.

Side Effects

Common side effects of codeine include pruritus, agitation, anxiety, constipation, diarrhea, hallucination, nausea, tremor, vomiting, and diaphoresis.

Common side effects of tramadol include dizziness, nausea, constipation, headache, and drowsiness.

Pricing and Coupons

Prices for both codeine and tramadol vary depending on the quantity and dosage. Lower-cost generic versions are available for both medications.

Dosage Form(s) Available

Both codeine and tramadol are available in oral tablet and oral liquid forms. Tramadol is also available in oral capsule and extended-release tablet forms.

Brand Names

Tramadol is sold under brand names like ConZip, Qdolo, and Tramadol Hydrochloride ER.

Half Life

The half-life of codeine is 3.5 hours, while the half-life of tramadol is 5.2 hours.

CSA Schedule

Codeine is a Schedule II controlled substance, while tramadol is a Schedule IV controlled substance.

Pregnancy Category

Both codeine and tramadol have pregnancy warnings and should only be used under medical supervision during pregnancy.

Drug Interactions

Both codeine and tramadol can interact with other medications, so it’s important to consult with a healthcare provider before taking them with other drugs.

Alcohol/Food/Lifestyle Interactions

Alcohol and medications containing alcohol should not be used with codeine or tramadol. Alcohol can also increase the side effects of tramadol like dizziness and drowsiness.

Disease Interactions

There are no known disease interactions for either codeine or tramadol, but it’s important to consult with a healthcare provider before taking them if you have any underlying medical conditions.

First Approval Date

Codeine was first approved on July 16, 2009, while tramadol was first approved on March 03, 1995.

WADA Class

Neither codeine nor tramadol are on the World Anti-Doping Agency’s list of prohibited substances.

More Information

For more information about codeine and tramadol, consult with a healthcare provider or refer to patient and professional resources.