Comparison between Codeine and Morphine

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Prescription Only

Codeine is a pain-reliever that can be addictive and cause constipation. Its effectiveness varies between individuals, so it should only be used for pain relief under medical supervision.

Morphine is a highly effective pain reliever but also carries a high risk of addiction and dependence. It can interact with other medications, which can increase the risk of side effects.

Check out popular comparisons between these medications.

Generic Status

Lower-cost generic versions of both codeine and morphine are available.

Ratings & Reviews

Codeine has an average rating of 7.8 out of 10 from 60 ratings on 69% of reviewers reported a positive effect, while 15% reported a negative effect.

Morphine has an average rating of 7.5 out of 10 from 368 ratings on 67% of reviewers reported a positive effect, while 14% reported a negative effect.

Drug Class

Both codeine and morphine belong to the opioid analgesics drug class.

Side Effects

See detailed information about potential side effects for both codeine and morphine.

Pricing and Coupons

Compare prices for different quantities and dosages of codeine and morphine.

Dosage Form(s) Available

Both codeine and morphine are available in various oral and injectable forms.

Brand Names

Morphine is sold under various brand names, while codeine is not currently available under any brand names.

Half Life

The half-life of codeine is 3.5 hours, while the half-life of morphine is 4 hours.

CSA Schedule

Both codeine and morphine are classified as Schedule II controlled substances under the Controlled Substances Act (CSA).

Pregnancy Category

See detailed warnings about using codeine and morphine during pregnancy.

Drug Interactions

Both codeine and morphine can interact with a large number of other medications, so it’s important to discuss all current medications with a healthcare provider before taking either drug.

Alcohol/Food/Lifestyle Interactions

Both codeine and morphine should not be used with alcohol or medications that contain alcohol.

Disease Interactions

Discuss any pre-existing medical conditions with a healthcare provider before taking codeine or morphine.

First Approval Date

Codeine was first approved on July 16, 2009, while morphine was first approved on May 29, 1987.

WADA Class

Neither codeine nor morphine are on the World Anti-Doping Agency (WADA) prohibited list.

More Information

Find additional patient and professional resources related to codeine and morphine.

Always consult a healthcare provider to ensure the information displayed applies to your personal circumstances.

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